丛羽生(Cong, Yu-Sheng)，男，博士， 1963年11月出生于吉林

     杭州师范大学医学院教授，博士生导师，基础医学研究院院长

     浙江省衰老与癌变生物学重点实验室主任

联系方式

杭州师范大学医学院衰老研究所

电话: 0571-2886-1693

Email: yscong@hznu.edu.cn

教育背景

博士：微生物生理与遗传，[法国]巴黎南大学/居里研究所，1994

硕士：分子生物学和生物化学，[法国]斯特拉斯堡大学，1989

学士：农学，吉林农业大学，1985

专业和研究方向

所从事的专业为细胞生物学。本实验室总体目标是通过对细胞衰老及无限增殖化的分子机理、端粒酶生物学功能等基础分子细胞生物学研究，探索正常人体细胞从年轻到衰老以及无限增殖化过程的分子生物学基础，为有效控制衰老、预防和治疗衰老相关疾病、探索肿瘤发生和发展的分子机理提供科学基础。

代表性论著(* corresponding author)

[1] Zhang Q, Liu N, Bai J, Zhou Q, Mao J, Xu L, Liu J, Wei H, Ren C, Wu X, Wang M, Zhao B*, Cong YS* (2020) Human telomerase reverse transcriptase is a novel target of Hippo-YAP pathway. FASEB J. 34(3):4178-4188. doi: 10.1096/fj.201902147R. Epub 2020 Jan 16

[2] Wang Z, Gong Y, Peng B, Shi R, Fan D, Zhao H, Zhu M, Zhang H, Lou Z, Zhou J, Zhu WG, Cong YS*, Xu X* MRE11 UFMylation promotes ATM activation. Nucleic Acids Res. 2019 May 7;47(8):4124-4135. doi: 10.1093/nar/gkz110.

[3] Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, Chen H, Wang M, Ju Z*, Cong YS* (2017) A critical role of DDRGK1 in endoplasmic reticulum homeostasis via regulation of IRE1α stability. Nature Communications. ;8:14186. doi: 10.1038/ncomms14186.

[4] Liu N, Ding D, Hao W, Yang F, Wu X, Wang M, Xu X, Ju Z, Liu JP, Song Z, Shay JW, Guo Y, Cong YS* (2016) hTERT promotes tumor angiogenesis by activation of VEGF through interaction with the Sp1 transcription factor. Nucleic Acids Res. 44:8693-8703. Epub 2016 Jun 20

[5] Zhou J, Mao B, Zhou Q, Ding D, Wang M, Guo P, Gao Y, Shay JW, Yuan Z, Cong YS* (2014) Endoplasmic reticulum stress activates telomerase. Aging Cell, 13:197–200

[6] Ding D, Xi P, Zhou J, Wang M, Cong YS* (2013) Human telomerase reverse transcriptase regulates MMP expression independent of telomerase activity via NF-κB-dependent transcription. FASEB Journal, (11):4375-83

[7] Bai L, Deng X, Li J, Wang M, Li Q, An W, A D, Cong YS* (2011) Regulation of cellular senescence by an essential caveolae component PTRF/Cavin-1. Cell Research 21：1088-1101

[8] Cong YS*, Wright WE, Shay JW (2002) Human telomerase and its regulation. Microbiology and Molecular Biology Reviews 66: 407-425

[9] Cong YS, Bacchetti S (2000) Histone deacetylation is involved in the transcriptional repres¬sion of hTERT in normal human cells. Journal of Biological Chemistry 275: 35665-35668

[10] Cong YS, Wen J, Bacchetti S (1999) The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter. Human Molecular Genetics 8 (1): 137-142