王欢欢（Wang，Huanhuan），女，博士，1983年11月出生于杭州

   杭州师范大学医学院副教授，硕士生导师，基础医学系副主任

联系方式

杭州师范大学慎园5-214

电话: 0571-2886-8887

Email: huanval@hznu.edu.cn

教育背景

2008/09-2012/06 德国慕尼黑大学医学院Adolf-Butenandt Institute生化系；德意志神经退行性疾病研究中心 自然科学博士

2006/09-2008/06 浙江大学药学院药理毒理与生化药学研究所 药理学 医学硕士

2002/10-2006/06 浙江大学药学院 药学 理学学士

专业和研究方向

主要从事神经退行性疾病相关分子机制的研究，研究重点为AD相关神经炎症和胶质细胞激活，代谢性疾病（如肥胖、糖尿病）与神经退行性疾病之间的内在联系，试图阐明环境因素或自身代谢因素对AD发生发展的影响。

主要工作简历

2012年获得德国慕尼黑大学医学院Adolf-Butenandt Institute（生理所）博士学位，所在工作组同时隶属于德意志神经退行性疾病研究中心（Deutsches Zentrum für Neurodegenerative Erkrankungen，DZNE）。2012年9月至今于医学院基础系生理教研室工作。目前已获得国家自然科学基金青年基金1项，浙江省自然科学基金2项，杭州市高层次留学回国人员（团队）在杭创业创新项目1项，相关研究成果已发表于EMBO J，FASEB Journal ，Food Chemistry等，发表SCI论文10余篇。

代表性论著

[1] Huanhuan Wang^#*, Guoping Peng^#, Bing Wang, Hongping Yin, Xingyue Fang, Fangping He, Dongjiu Zhao, Qibing Liu, Liyun Shi^* IL-1R^-/- alleviates cognitive deficits through microglial M2 polarization in AD mice. Brain Research Bulletin 2020, 157: 10-17.

[2] Chaoqun Wang, Yikai Shou, Jie Pan, Yue Du, Cuiqing Liu, Huanhuan Wang^* The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism. Nutritional Neuroscience 2019, 22(7): 453-463.（[3] 2019.6.15 Yikai Shou^#, Yilu Huang^#, Xiaozheng Zhu, Cuiqing Liu, Yu Hu^*, Huanhuan Wang^* A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease. Ecotoxicology and Environmental Safety 2019, 174: 344-352.

[4] Huanhuan Wang^#, Yikai Shou^#, Xuan Zhu^*, Yuanyuan Xu, Lihua Shi, Shasha Xiang, Xiao Feng, Jianzhong Han Stability of vitamin B12 with the protection of whey proteins and their effects on the gut microbiome. Food Chemistry 2019, 276: 298-306.

[5] Huanhuan Wang^#, Wenhai Huang^#, Meihao Liang, Yingying Shi, Chixiao Zhang, Qin Li, Meng Liu, Yikai Shou, Hongping Yin, Xiaozheng Zhu, Xiaoyan Sun, Yu Hu, Zhengrong Shen^* (+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling. Cell & Bioscience 2018, 8(60): 1-15.

[6] Huanhuan Wang^*, Bing Wang, Hongping Yin, Guoqing Zhang, Liping Yu, Xiangmin Kong, Haiying Yuan, Xingyue Fang, Qibing Liu, Cuiqing Liu, Liyun Shi^* Reduced neurotrophic factor level is the early event before the functional neuronal deficiency in high-fat diet induced obese mice. Metabolic Brain Disease 2017, 32: 247-257.

[7]  Meng Qian, Xiaoqiang Shen, Huanhuan Wang^* The Distinct Role of ADAM17 in APP proteolysis and microglial activation related to Alzheimer’s disease. Cellular and Molecular Neurobiology 2016, 32: 471-482.

[8]  Peer-Hendrik Kuhn^#, Huanhuan Wang^#, Bastian Dislich, Alessio Colombo, Ulrike Zeitschel, Joachim W. Ellwart, Elisabeth Kremmer, Steffen Roßner, Stefan F. Lichtenthaler^* ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons. EMBO Journal 2010, 29(17): 3020-3032.

[9]  Zhiqiang Wang^#, Huanhuan Wang^#, Jiaying Wu, Danyan Zhu, Xiangnan Zhang, Lili Ou, Yongping Yu, Yijia Lou^* Enhanced co-expression of β-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner. Chemico-Biological Interactions 2009, 179(2-3): 375-385.