刘江，博士，1983年11月出生于河南

      杭州师范大学医学院副教授，硕士生导师

联系方式

杭州师范大学医学院衰老研究所

电话: 0571-2886-9357

Email: liujiang1120@126.com

教育背景

博士：生物化学与分子生物学，华东师范大学，2008-2012

博士联合培养：细胞与分子生物学，美国贝勒医学院，2010-2012

硕士：生物医学，华东师范大学，2006-2008

学士：生物科学，河南师范大学，2002-2006

专业和研究方向

所从事的专业为细胞与分子生物学。主要研究方向为蛋白质修饰与降解的调控机制。通过构建相关肿瘤模型和代谢性疾病动物模型，结合临床病患样本，深入研究蛋白质修饰与降解调控在炎症应激反应、肿瘤胁迫应激反应和代谢应激反应的作用机制，在蛋白质修饰、转录因子调控、细胞周期与凋亡、糖脂代谢和信号转导等方面进行重要基因的功能阐述，以期待寻找新的疾病标记物和治疗靶标。

主要工作简历

2013年入职杭州师范大学医学院衰老研究所；2017年入选杭州市131人才计划和杭州师范大学卓越人才计划；2018年入选浙江省“院士结对培养青年英才”计划，同年入选杭州师范大学卓越拔尖人才计划。先后主持国家自然科学基金、浙江省自然科学基金等6项，在Nature Communications, PNAS, JBC, JCS 等发表论文10多篇。

代表性论著

[1] Jiang Liu^#, Ying Wang^#, Lizhi Song, Linghua Zeng, Weiwei Yi, Ting Liu, Huanzhen Chen, Miao Wang, Zhenyu Ju*, Yu-Sheng Cong*. A critical role of DDRGK1 in endoplasmic reticulum homeostasis via regulation of IRE1α stability. Nature Communications. 2017 Jan 8:14186 (^# co-first)

[2] Jiang Liu^#, Ying Wang^#, Lei Li, Li Zhou, Haibin Wei, Qingxia Zhou, Jian Liu, Weicang Wang, Lei Ji, Peipei Shan, Yan Wang, Yuanyuan Yang, Sung Yun Jung, Pei Zhang, Chuangui Wang, Weiwen Long, Bianhong Zhang*, Xiaotao Li*. Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions. J Biol Chem. 2013, 288:16567-16578. (^# co-first)

[3] Xiao Gao^#, Qingwei Wang^#, Ying Wang^#, Jiang Liu^#, Shuang Liu^#, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Jiwei Chen, Da Wang, Linian Pan, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Yongyan Dang, Geng Chen, Jun Qin, Lan Huang, Pei Zhang, Robb E. Moses, David M. Lonard, Bert W. O’Malley, Bianhong Zhang*, Xiaotao Li*, Lei Li*, Jianru Xiao*. NIP30 a REGgamma inhibitor, accentuates anticancer sensitivity in p53-deficient tumor cells. Nature Communications. 2020, accepted (^# co-first)

[4] Jiang Liu, Zhi Tong, Zaichao Zhang, Yujing Weng, Xiyun Ye*. Empirical study of flavone from hawthorn biloba in preventing and treating insulin resistance and fatty liver in rats. Journal of East China Normal University (Natural Science), 2008 (6): 127-132

[5] Jinjin Xu^#, Lei Zhou^#, Lei Ji^#, Fengyuan Chen^#, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O’Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao*, Alexander Hoffmann*, Xiaotao Li*. The REGγ-proteasome forms a regulatory circuit with IĸBε and NFκB in experimental colitis. Nature Communications. 2016 Feb 22;7:10761

[6] Shuang Liu^#, Li Lai^#, Qiuhong Zuo, Fujun Dai, Lin Wu, Yan Wang, Qingxia Zhou, Jian Liu, Jiang Liu, Lei Li, Qingxiang Lin, Chad J. Creighton, Myra Grace Costello, Shixia Huang, Caifeng Jia, Lujian Liao, Honglin Luo, Junjiang Fu, Mingyao Liu, Zhengfang Yi*, Jianru Xiao*, Xiaotao Li*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014,72,28-38

[7] Amjad Ali^#, Zhuo Wang^#, Junjiang Fu^#, Lei Ji, Jiang Liu, Lei Li, Hui Wang, Jiwu Chen, Carlos Caulin, Jeffrey N. Myers, Pei Zhang, Jianru Xiao, Bianhong Zhang*, Xiaotao Li*. Differential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells. Nature Communications. 2013 Oct 4:2667

[8] Lei Li^#, Dengpan Zhao^#, Haibin Wei, Liangfang Yao, Yongyan Dang, Ali Amjad, Jinjin Xu, Jiang Liu, Linjie Guo, Dongqing Li, Zhen Li, Di Zuo, Yuanyuan Zhang, Jian Liu, Shixia Huang, Caifeng Jia, Lu Wang, Ying Wang, Yifan Xie, Jian Luo, Bianhong Zhang, Honglin Luo, Lawrence A. Donehower, Robb E. Moses, Jianru Xiao*, Bert W. O’Malley*, Xiaotao Li*. REGγ deficiency promotes premature ageing via the CK1δ-Mdm2-p53 pathway. Proc Natl Acad Sci U S A. 2013,110,11005–11010